Frank-Starling mechanism and short-term adjustment of cardiac flow
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منابع مشابه
Frank-Starling mechanism and short-term adjustment of cardiac flow.
The Frank-Starling law of the heart is a filling-force mechanism (FFm), a positive relationship between the distension of a ventricular chamber and its force of ejection, and such a mechanism is found across all the studied vertebrate lineages. The functioning of the cardiovascular system is usually described by means of the cardiac and vascular functions, the former related to the contractilit...
متن کاملFrank-Starling relationship: long on importance, short on mechanism.
The Frank-Starling relationship is an intrinsic property of myocardium by which increased length (or ventricular volume) results in enhanced performance during the subsequent contraction.1–3 This relationship appears to be very important in cardiac function because increased venous return and the corresponding increase in end-diastolic volume result in greater stroke volume during the next beat...
متن کاملThe Frank-Starling mechanism in vertebrate cardiac myocytes.
The Frank-Starling law of the heart applies to all classes of vertebrates. It describes how stretch of cardiac muscle, up to an optimum length, increases contractility thereby linking cardiac ejection to cardiac filling. The cellular mechanisms underlying the Frank-Starling response include an increase in myofilament sensitivity for Ca2+, decreased myofilament lattice spacing and increased thin...
متن کاملWho discovered the Frank-Starling mechanism?
In 1866 at Carl Ludwig's Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.
متن کاملRole of the Frank-Starling mechanism in exercise.
The mechanisms which determine the response of stroke volume to mild, moderate, and severe exercise were compared in nine dogs running on a level treadmill. The dogs ran for 3-minute periods at 3-^ mph (mild exercise), 6-8 mph (moderate exercise), and 10—14 mph (severe exercise). Heart rate increased from a standing control value of 107 ± 6 beats/min to 191 ± 10 beats/min in mild, 221 ± 8 beats...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2017
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.167106